FORMULATION AND EVALUATION OF PANTOPRAZOLE BUCCAL PATCHES

Buccal delivery of the desired drug using mucoadhesive polymers has been the subject of interest since the early 1980s. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of pantoprazole which offers an attractive route of administration for systemic drug delivery. Pantoprazole (dose, 10-40mg) is proton pump inhibitor used in treatment of erosion and ulceration of the esophagus caused by gastro esophageal reflux disease. Its oral bioavailability is 77% metabolized in the liver by cyp-450 system. The patches were prepared and evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, and In vitro release studies were conducted for pantoprazole loaded patches in phosphate buffer (pH, 7.4) solution.