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Serum Vascular Endothelial Growth Factor VEGF and Interlukin-8 As a Novel Biomarkers For Early Detection of Ovarian Tumors

Journal: Baghdad Science Journal (Vol.12, No. 2)

Publication Date:

Authors : ; ; ;

Page : 293-300

Keywords : Ovarian cancer; VEGF; IL8; Serum;

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Abstract

Epithelial ovarian cancer is the leading cause of cancer deaths from gynecological malignancies. Angiogenesis is considered essential for tumor growth and the development of metastases. VEGF and IL−8 are potent angiostimulatory molecules and their expression has been demonstrated in many solid tumors, including ovarian cancer. VEGF and IL-8 concentrations were measured by ELISA test (HumanVEGF,IL-8). Bioassay ELISA/ US Biological / USA). The median VEGF and IL-8 levels were significantly higher in the sera of ovarian cancer patients than in those with benign tumors and in healthy controls. Pretreatment VEGF and IL-8 serum levels might be regarded as an additional tool in the differentiation of ovarian tumors.

Last modified: 2015-06-20 17:47:47