Molecular Insight into Integrin Alpha Beta 6 Receptor of Cattle and their Relationship with FMD Infectivity

Foot and mouth disease (FMD) of cattle, which causes severe economic losses, is caused by the virus under the family of Picornaviridae. There are total seven serotypes viz. A, O, C, Asia-1and South African Territories 1 (SAT1), SAT2, and SAT3 of FMDV was identified, among them serotype O are most prevalent in India. The virus exhibits a strong tropism for the epithelial cells, during natural infection of FMD the viral entry into the host as well as the replication machinery take place in the pharynx as well as soft palate. During viral infection inside the host system the observable lesions developed on feet and mouth (7-8).