A New method for ISE construction for methyl orange dyes and using for indirect determination of Amitriptyline Hydrochloried drug

A new method for construction ion-selective electrode (ISE) by heating reaction of methyl orange with ammonium reineckate using PVC as plasticizer for determination methyl orange and determination Amitriptyline Hydrochloried drug by formation ion-pair on electrode surface . The characteristics of the electrode and it response as following : internal solution 10-4M , pH (2.5-5) ,temperature (20-30) and response time 2 sec. Calibration response for methyl orange over the concentration range 10-3 -10-9 M with R=0.9989 , RSD%=0.1052, D.O.L=0.315X10-9 M Ere%=(-0.877- -2.76) , Rec%.=(97.230 -101.711) .