Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran
Journal: Molecular Biology Research Communications (Vol.4, No. 2)Publication Date: 2015-06-01
Authors : Parisima Behbahani; Seyed Reza Kazemi Nezhad; Ali Mohammad Foroughmand; Leila Ahmadi;
Page : 67-72
Keywords : Bipolar mood disorder; COMT gene; rs165599; Schizophrenia;
Abstract
Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association between the mentioned disorders and a genetic polymorphism (rs165599) of catechol O-methyltransferase (COMT, OMIM: 116790) was studied. Here 100 BPD patients, 100 SCZ patients, and 100 healthy controls were included in the study. The samples were matched in terms of gender and ethnicity. Statistical analysis showed that there was a significant association this polymorphism and risk of SCZ. The AG (OR=7.41, 95% CI: 3.21-17.1, P
Other Latest Articles
- Distribution of ACE insertion/deletion (I/D) polymorphism in Iranian populations
- Inference Attacks and Control on Database Structures
- Discourse marker acquisition and out-of-school activities: evidence from EFL writing
- Diagnosis of the Potential for Successful Implementation of a Knowledge Management System in a University Unit member
- Contents of Global Talent Evaluations: Baltics & Serbia
Last modified: 2015-06-22 13:09:30