In vivo Growth Kinetics of the Natural Course of an Undifferentiated Untreated Endometrial Cancer: An Observational Case Report
Journal: Journal of Andrology & Gynaecology (Vol.1, No. 2)Publication Date: 2013-12-30
Authors : Edgar Petru; Peter Regitnig; Manuela Aschauer; Haro Stettner;
Page : 01-03
Keywords : Endometrial cancer; Natural course of disease; In vivo Growth kinetics; Metastasis;
Abstract
We describe a patient with a histologically verified undifferentiated endometrial cancer who initially declined treatment, thus permitting study of the in vivo growth kinetics of the tumor. 266 days later, the patient was diagnosed with extensive symptomatic pelvic, abdominal, mediastinal, lung and supraclavicular metastases confirmed by imaging. During the untreated phase of 9.2 months, the tumor volume doubling time was estimated to be 56 + 3.5 (SD; standard deviation) days when an exponential tumor growth was assumed. This rapid growth was paralleled by immunohistochemistry showing a higher mitotic rate in the metastasis than in the primary tumor. At a late stage of the disease, laparotomy showed pelvic extension of the endometrial tumor, parenchymal liver metastasis and peritoneal carcinomatosis. The patient died 1.5 years after the initial diagnosis. To the authors´ knowledge, this is the first analysis of hypothetically generated exponential tumor kinetics of an untreated gynecological cancer in vivo. This report may serve as a reference for assessing future clinical interventions in endometrial cancer.
Other Latest Articles
- Transvaginal Bladder Neck Closure Revisited: A Less Invasive Approach to the Management of a Destroyed Urethra
- Sexual health promotion using social networks in Spain
- Changes in Male Testosterone Levels over the Last Century As Reflected In Facial Width-Height Ratios
- Designing the Rehabilitation of Men with Post-Prostatectomy Erectile Dysfunction Using a Pre-and Post-Operative Approach
- Mechanical Bowel Preparation for Laparoscopic Gynecological Surgery: Controversy Continues
Last modified: 2015-06-22 17:48:52