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Chemokine Receptors as Biomarkers in Head and Neck Squamous Cell Carcinoma

Journal: Journal of Oncobiomarkers (Vol.1, No. 1)

Publication Date:

Authors : ; ;

Page : 1-3

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is reported to be the 6th most common solid tumor diagnosed in the world [1]. Around 95% head and neck cancers are squamous cell carcinomas originating in the upper aerodigestive epithelial cells [2]. Despite continuous research efforts and progresses in diagnostic and therapeutic strategies, the mortality rates have not significantly changed over the past several decades [3]. Moreover, the five-year survival rate of HNSCC after diagnosis is considerably lower than that of other cancers, such as cervix, colorectal and breast cancer [4,5]. The reason for the limited five-year survival rate of HNSCC could be advanced disease stages, failure in early diagnosis and low efficiency of therapeutic strategies [6,7]. The death of HNSCC is mainly caused by invasion along with regional and/or distant metastatic spreading of tumor cells from primary tumor lesions [8]. Therefore, the key point of the treatment of head and neck cancers is early diagnosis.

Last modified: 2015-06-23 18:51:56