Antimicrobial Activities Of Synthesized ZincII Mixed-Ligand Complexes Derived From 2-Acetylpyridine-4-Phenylsemicarbazone And Nitrogen-Sulphurmonodentate Ligands

Abstract The reaction of zinc chloride with 2-acetylpyridine-4-phenylsemicarbazone and nitrogensulphurmonodentate ligands such as thiophene pyridine picoline aniline and ammonia yielded five novel mixed -ligand complexes Zn2-Ac.4-Psc.ThCl2 Zn2-Ac.4-Psc.PyCl2 Zn2-Ac.4-Psc.PiCl2 Zn2Ac.4-Psc.AnCl2 and Zn2-Ac.Psc.AmCl2. These were characterized by elemental analysismolar conductivity1H and 13C-NMR IR and electronic absorption spectroscopic studies.All the complexes possess tetrahedral geometries. The antimicrobial activities were evaluated against staphylococcus aureus Bacillus anthracisAspergillusnigers andCandida albicans.The result of significant inhibition of growth and proliferation of these microbes by the chelates were obtained particularly with the highest efficiency shown by thethiophene and aniline incorporated complexes