Effect of Geumgoeshingi-Whan Pharmacopuncture on the Blood Pressure in Spontaneously Hypertensive Rats
Journal: Journal of Pharmacopuncture (Vol.16, No. 1)Publication Date: 2013-03-31
Authors : Meesun Lee; Sangmi Lee; Hohyn Jeong; Manyong Park; Dong-woung Kim; Bong-keun Song; Jong-Deok Lee; Ho Sub Lee; Sungchul Kim;
Page : 37-42
Keywords : Geumgoeshingi-whan; Pharmacopuncture; SHR; hypertension; ANP; Renal function;
Abstract
Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats(SHR). Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks. Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP). Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.
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