5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine
Journal: Journal of Acupuncture and Meridian Studies (Vol.3, No. 2)Publication Date: 2010-06-30
Authors : Chul-Ho Cho; Jong-Sup Bae; Yong-Ung Kim;
Page : 116-118
Keywords : androgen-dependent diseases; anthraquinone; emodin; Polygoni Multiflori Radix; 5α-reductase inhibitor; Polygonum multiflorum Thunb;
- 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine
- Inhibitory Effects of Isoflavonoids on Rat Prostate Testosterone 5α-Reductase
- Effects of Herbal Medicine (Gan Mai Da Zao Decoction) on Several Types of Neuropsychiatric Disorders in an Animal Model: A Systematic Review Herbal medicine for animal studies of neuropsychiatric diseases
- INHIBITORY ACTIVITIES OF ALKALOID FROM COCCINIA GRANDIS AGAINST ALDOSE REDUCTASE AND GENERATION OF ADVANCED GLYCATION ENDPRODUCTS
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Abstract
We investigated medicinal plant sources with 5α-reductase inhibitory activity. These compounds have been used in several remedies against androgen-dependent diseases including benign prostatic hyperplasia. The 50% ethanol extract of Polygonum multiflorum Thunb (Polygoni Multiflori Radix; Polygonaceae) showed potent 5α-reductase inhibitory activity. The fraction responsible for this activity was purified, and the active constituent was isolated and identified as emodin, an anthraquinone compound. Although emodin showed considerably less potent inhibitory activity than riboflavin, the inhibitory activity of the compound was more potent than that of alizarin (1,2-dihydroxyanthraquinone), an anthraquinone-type positive control. Also, anthraquinone itself was substantially inactive against 5α-reductase, in dicating that the hydroxyl group on the structure of emodin is an important structural moiety for displaying inhibitory activity.
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