Anticonvulsant Effect of Berberis integerrima L. Root Extracts in Mice
Journal: Journal of Acupuncture and Meridian Studies (Vol.6, No. 1)Publication Date: 2013-02-28
Authors : Hossein Hosseinzadeh; Mohammad Ramezani; Hojjat Shafaei; Elahe Taghiabadi;
Page : 12-17
Keywords : anticonvulsant; Berberis integerrima; herbal; maximal electroshock seizure; pentylenetetrazole; seizure;
Abstract
Berberis integerrima is a member of Berberidaceae family. Berberine is one of the main constituents of this plant, having neuroprotective effect on central nervous system diseases. In this study, the anticonvulsant activity of methanolic extract, and hydromethanolic fraction, and chloroform fraction of B integerrima was assessed. The anticonvulsant effect of B integerrima was investigated using both pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizure models. The LD50 value of the methanolic extract was 302.676mg/kg. In the PTZ test, methanolic extract (140 and 200mg/kg, i.p., p
Other Latest Articles
- Chinese Herbs for Memory Disorders: A Review and Systematic Analysis of Classical Herbal Literature
- Medicinal Plants for the Treatment of Uterus Inflammation: Implications from Iranian Folk Medicine
- Inhibitory Effects of Isoflavonoids on Rat Prostate Testosterone 5α-Reductase
- Ameliorative Effects of Syzygium jambolanum Extract and its Poly (lactic-co-glycolic) Acid Nano-encapsulated Form on Arsenic-induced Hyperglycemic Stress: A Multi-parametric Evaluation
- Hypotensive Effects Induced by Herbal Fomentation at Yongquan Point
Last modified: 2015-07-16 14:43:13