Evaluation of Bacopa monniera for its Synergistic Activity with Rivastigmine in Reversing Aluminum-Induced Memory Loss and Learning Deficit in Rats
Journal: Journal of Acupuncture and Meridian Studies (Vol.6, No. 4)Publication Date: 2013-08-31
Authors : Agadi Hiremath Thippeswamy; Mohamed Rafiq; Gollapalle Lakshminarayana shastry Viswantha; Kethaganahalli J. Kavya; Suryakanth D. Anturlikar; Pralhad S. Patki;
Page : 208-213
Keywords : aluminum chloride; Bacopa monniera; elevated plus maze; memory impairment; Morris water maze; rivastigmine;
Abstract
The objective of this study was to evaluate the synergistic activity of Bacopa monniera with Rivastigmine against aluminum-chloride (AlCl3)-induced cognitive impairment in rats. Adult male Wistar rats were divided into ten groups (n = 10) and subjected to their assigned treatments for 42 days. On the 20th day of the respective drug treatments, all the animals were trained in the Morris water maze (retention latency) and the elevated plus maze (transfer latency). After the initial training, the retention latency (RL) and the transfer latency (TL) were evaluated on the 21st and the 42nd days of the study. Chronic administration of AlCl3 caused significant memory impairment associated with increased RL in the Morris water maze task and increased TL in the elevated plus maze test. Interestingly, animals treated with oral administration of B. monniera (100 and 200 mg/kg), Rivastigmine (5 mg/kg) or a combination of B. monniera (100 mg/kg) with Rivastigmine (5 mg/kg) showed significant protection against AlCl3-induced memory impairment compared to animal treated with AlCl3 per se. Additionally, the neuroprotective effect of B. monniera (100 and 200 mg/kg) was significantly improved when supplemented with Rivastigmine (5 mg/kg). These findings suggest that treatment with a combination of B. monniera with Rivastigmine may be highly beneficial compared to their per-se treatment.
Other Latest Articles
- Effects of Extracts and Fractions of Gynura procumbens on Rat Atrial Contraction
- Anticancer Potential of Myricanone, a Major Bioactive Component of Myrica cerifera: Novel Signaling Cascade for Accomplishing Apoptosis
- The Potentized Homeopathic Drug, Lycopodium clavatum (5C and 15C) Has Anti-cancer Effect on HeLa Cells In Vitro.
- Cupping Therapy and Palliative Care: What about Hematologic Malignancies?
- Pain along the Gall Bladder Meridian in 100 Horses
Last modified: 2015-07-16 14:47:33