Liquid-Liquid Extraction vs Solid Phase Extraction in Biological Fluids and Drugs

Biological fluids have complicated matrix and it is quite hard task to analysis the interest free from admixtures in the matrix. Traditionally liquid/liquid extraction (LLE) is employed for the analysis of biological compounds, based upon the manipulation of aqueous pH to extract drugs into organic solvent(s) with several sort of polar. This method is used on a variety of specimens including blood, urine, bile, gastric contents, and tissue homogenates and acidic, neutral, and alkaline drugs may be extracted in one analytical scheme.