SIRT7: from a Metabolic Regulator to a Disease Marker

Acetylation regulation plays an important role in various kinds of physiological processes, dysregulation of which leads to pathological progression and serious diseases. SIRTuin family, a class III HDACs, has drawn more and more attention due to its increasing vital biological functions. In case of cancer progression, some of which has been demonstrated to serve as either tumor suppressor or oncogene or both, which depends on context and/or cell type. Here we summarized the roles of SIRT7 in cancer progression and discussed its therapeutic potential in cancer treatment.