Development and Evaluation of an Aqueous Polymeric Dispersion of Eudragit L 100-55 Using Emulsification Technology

Aqueous polymer dispersions (APD) are preferred on environmental and safety grounds. APD offer several advantages over polymers dissolved in organic solvents including lower spraying viscosities, higher solids loading, higher spray rates, no solvent environmental, toxicity, or flammability issues, and reduced energy requirements. The purpose of this work is to prepare and characterize an aqueous-based pseudolatex dispersion of Eudragit L100-55 using emulsification technology with superior stability. The prepared APD is evaluated on the basis of organoleptic, physical, chemical and in-vitro drug release performance. APD film is prepared by casting method and evaluated. Coating is done over Diclofenac sodium tablet and In vitro drug release profile of APD coated tablet and organic coated tablet is studied and shows better release in case of APD as compared to market formulation and organic coating.