DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 4- (2,3-DIHYDRO-4H-PYRIDO[3,2-B][1,4]OXAZIN-4-YL)-3- FLUOROANILINE DERIVATIVES

A series of seven compounds 4-(2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)-3-fluoroaniline derivatives (5I e ? 5I k) was prepared from commercially available 2-Amino-3-Hdroxy Pyridine. The morpholine, pyridine, fluorine, aniline and amides were introduced in our moiety considering the better biological results in vaster range of therapeutic area. The compound bearing such moieties gives good bio-active data. The more yield and good quality of the synthesized product was shows that there is no side reaction and by product while the organic synthesis. The structure confirmation of the synthesized molecules was confirmed by means of proton nuclear magnetic resonance spectroscopy and LC-MS spectroscopy. The synthesized NCE’s were further tested for their antibacterial and antifungal studies. Some of the molecules were identified to show better antibacterial and antifulgul activity. Keywords: Pyridine morpholine, Morpholine, Fluoroaniline, Antibacterial, Antifungal.