PREPARATION AND IN VITRO EVALUATION OF ETODOLAC EXTENDED RELEASE TABLETS PREPARED BY WET GRANULATION METHOD EMPLOYING KOLLIDON® SR

Background: The most prominent advantages of extended release formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are their ability to maintain optimal and therapeutically effective drug levels for prolonged duration with reduction in dosing frequency and side effects associated with NSAIDs. Aim: The objective of the present study to develop diffusion controlled matrix tablets for extended release of a model NSAID drug, Etodolac. Materials and Methodology: Etodolac control release tablets were prepared by wet granulation method using Kollidon® SR in different ratios as release rate controlling polymers. The granules were evaluated for flow properties by evaluating bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose. The tablets were evaluated for drug polymer compatibility study by FTIR, diameter, weight variation test, hardness, friability, disintegration test, in vitro drug release, release kinetics and stability studies. Results and Discussions: The FTIR study revealed that no such interactions being taking place in between drug and polymers. The flow property of granules of all tablet batches was found to be good. All the tablet formulations had good tablet physiochemical properties. In-vitro release data showed dependence of release kinetics on different percent of drug to polymer in cross-linked matrix systems. Conclusion: The results of in vitro study, it was concluded that Etodolac matrix tablet containing Kollidon® SR (10.0 %) provided most controlled release of water-soluble Etodolac over extended period of time. Keywords: Extended release, NSAIDS, Etodolac, matrix tablet, wet granulation.