Design and Synthesis of New Series of One Pot Schiff Bases of 4-Aminobenzenesulfon- Amideas Potent Antibacterial and Anti-Fungal Agents

Schiff bases are imines formed by the condensation of a primary amine and a carbonyl compound. These classes of compounds are very important due to their wide range of biological activities and industrial applications. In this study, some Schiff bases (coded GAS1-5) were synthesized by condensation of 4?Aminobenzenesulfonamide and some selected carbonyl molecules via MW irradiation for 1 minute at 385 watt power; and were characterized by FT-IR and elemental analyses. These Schiff bases were then evaluated for their bactericidal effects against two Gram positive and two Gram negative bacteria (Staphylococcus aureus, Bacillus subtilis and Escherichia coli, Pseudomonas aeruginosa respectively) and for their fungicidal activities against one fungus (Candida albicans). Their biocidal activities were also evaluated against one standard antibacterial drug, Zyprox (Ciprofloxacin), and one standard antifungal drug , Nizoral (ketoconazole), in the market. All the synthesized bases, except one, exhibited interesting antimicrobial activities against the selected microbes; some even exhibited better biocidal effects at the chosen concentration for this work (5μM) than the standard commercial reference drugs used in this study.