FORMULATION AND INVITRO EVALUATION OF BUCCAL DRUG DELIVERY SYSTEM OF VENLAFAXINE HYDROCHLORIC ACID TABLETS

In the present study Bilayer buccal tablets were formulated by using ethyl cellulose as backing membrane. From the foregoing investigation it might be close that rate of drug release from the buccal tablets can be govern by the polymer and concentration of the polymer used in the preparation of tablets. Synchronized drug release in first order approach attain in the current study indicates that the hydrophilic matrix tablets of Venlafaxine HCl was prepared using Carbopol 934 and HPMC K100 can successfully be employed as a buccoadhesive controlled released during delivery system. The pre compression mix for all formulations contains various estimation parameters and the outcome found to be within limits. The post compression parameters for all the formulations also originate to be within limits. Slow, controlled and complete release of Venlafaxine HCl over a episode of 9 hours be obtains from matrix tablets formulated HPMC K 100 (F5 Formualtion) with 93.62 % drug release. Keywords: Bilayer buccal tablet, Venlafaxine HCl , HPMC, Carbopal.