COORDINATION OF BINUCLEATING SCHIFF BASE WITH Cu(II), Co(II), Ni(II) AND Mn(II) IONS; DESIGNING, STRUCTURAL ASPECTS AND PHARMACOLOGICAL PROPERTIES

A new series of binuclear Schiff base Cu(II), Co(II), Ni(II) and Mn(II) complexes have been synthesized with Schiff base derived from Benzene-1,4-dicarbaldehyde, 2,6-diaminopyridne, 2-hydroxynaphthalene-1-carboxaldehyde and 2,2’bipyridyl. The chelation of the metal complexes has been proposed in the light of analytical, spectral (IR, UV?Vis), magnetic, 1H NMR and ESR studies. These data reveals that the Schiff base acts as a dibasic and the complexes exhibit the hexa-coordinated geometry. The Schiff base and their metal complexes have been screened for their antibacterial, antifungal and antioxidant activities. The results of these studies show the metal complexes to be more antifungal and more significant antioxidant as compared to free Schiff base ligand. Also the antibacterial activity depends on the solvent used during the experiment. All the metal complexes cleave the pUC18DNA in presence of H2O2.