Progressive multifocal leukoencephalopathy in non HIV, splenectomised, 66 years old male ? A rare case report

Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive AIDS-defining disease of the central nervous system. PML affects up to 8% of patients with AIDS and in most cases is fatal within 3?5 months. We presented here a case of 66 years old male who is non HIV with past history of splenectomy, and diagnosed as progressive multifocal leukoencephalopathy which is very rare. Here, we presented this rare entity which may be difficult to diagnose although, histopathological examination helps greatly in the diagnosis of this condition but the specificity and sensitivity of JC virus DNA PCR in CSF are quite acceptable.