Mifepristone Plus Vaginal Misoprostol V/S Vaginal Misoprostol Alone for Medical Termination of Pregnancy

Medical abortion has been investigated as a non-invasive option for early abortions as it avoids the risk of anesthesia and surgical trauma to the cervix, uterus and other organs. The main aim of the study was to compare the efficacy and safety of abortion using the drugs mifepristone and vaginal misprostol V/s misoprostol alone. A randomized control study was done in 100 women who came for termination of pregnancy up to 63 days in family planning unit at Government Medical College Hospital, Kottayam, India for one year period. The mean age of the study group was 25.4 years of age. Complete abortion occurred in 94% with Mifepristone and Misiopristol regime (Group A) and 86% of Misoprostol alone regimn(Goup B). There was a 100% complete abortion rate with mifepristone and misoprostol in POGs up to 49 days. Complete abortion showed better compliance with Misoprolstol alone regimn in Primigravida (100%) and, Mefepristone and Misoprostol regime with multigravida (97%). The mean period of bleeding was 5.7 in Group A and 7.6 in Group B. Mifepristone and Misiopristol regime showed better outcome than Misoprostol alone for medical termination of pregnancy till first 9 weeks of gestation. Keywords: Mifepristone, Misiopristol, Medical termination of pregnancy Abbreviations: MTP -Medical Termination of Pregnancy IUD -Intra Uterine Device MVA - Manual Vacuum Aspiration EVA - Electric Vacuum Aspiration D&E - Dilatation and Evacuation