Association Between the Polymorphism of the Angiotensin - Converting Enzyme Gene and Breast Cancer Risk Among the Bengalee Caste Hindu Females of West Bengal, India

Carcinoma of the breast is the most common malignancy among women all over the world. There are a number of risk factors associated with the disease. There is an inter-individual variability in breast cancer risk that attracts that is of anthropological interest. Many studies attempted to find the association between the ace polymorphism (287bp I/D) and prognosis of breast cancer. This study attempted to study the prevalence of ace polymorphism among 108 pathologically confirmed breast cancer patients and 128 controls. The frequency of dd genotype in the malignant samples (57.4%) was higher than the control group (25.0%), having a significant association with breast cancer risk (or 4.232, 95%ci=0.083 ? 0.229, p < 0.0001). The present findings suggest that the DD genotype may constitute a powerful tool in determining the occurrence and prognosis of breast carcinoma among the Bengalee Hindu caste females from West Bengal.