Variant Translocation of ETV6 and RUNX1 in a Case of Pediatric Acute Lymphoblastic Leukemia

Rearrangement of ETV6 (or TEL) gene at chromosome 12p13 region has been reported in several hematopoietic malignancies. About 25% of pediatric B cell Acute Lymphoblastic leukemia (BALL) cases have t(12;21) translocation involving ETV6 locus at 12p13 and RUNX1 locus at 21 q 22(1, 2) and is associated with a good event free survival. Many of these cases may have additional aberrations in addition to poor morphology. Variant and complex translocations of t(12;21) involving an additional chromosome have been reported in several cases of ALL.