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Treatment of Lentigomaligna in Dark Skin with Topical Imiquimod Results in Dark Hyperpigmentation

Journal: International Journal of Clinical Dermatology & Research (IJCDR) (Vol.02, No. 03)

Publication Date:

Authors : ; ;

Page : 19-20

Keywords : Imiquimod; Dark Skin; LentigoMaligna; Post-Inflammatory Hyperpigmentation.;

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Abstract

LentigoMaligna (LM) is an in situ lesion with a low risk of progression to LM Melanoma (LMM). Treatment of LM is mostly advocated because an invasive component of LMM might be lethal. Recently topical Imiquimod 5% cream was introduced as a new treatment possibility. We describe here a patient, with skin type IV, with a hyperpigmented LM eruption at his forehead. The lesion was treated 4 weeks with topical Imiquimod 5%, 5 times a week for 8 weeks. Four weeks after cessation of treatment the macular lesion appeared enlarged and darker indicating lack of response. Punch biopsies revealed post-inflammatory hyperpigmentation (PIH) and ruled out LM and LMM. During 6 moths observation the skin normalized. The present case is a reminder that dark skin comprises an increased risk of PIH that when induced by Imiquimod treatment of LM can be mistaken as lack of therapeutic efficacy or progression to LMM.

Last modified: 2015-10-26 14:23:19