COMPARATIVE STUDY OF DIFFERENT ANTIDEPRESSANTS IN NORMAL, SLEEP DEPRIVED AND DIABETIC MICE

According to WHO report, approximately 450 million people suffer from a mental or behavioral disorder. Worldwide, depression is the most common affective disorder and a major cause of disability and premature death. The prevalence of depression is higher in diabetic and hypertensive patients than in the general population. There is an increasing evidence that sleep may be important for learning and memory where as sleep deficit results in performance impairment (depression) both in rodents and humans. Hence, the study was prompted to investigate whether the conventionally used dose of antidepressants are effective in (disorded and diseased) sleep deprived and diabetic depressive patients.