FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF KETOROLAC TROMETHAMINE BY USING NATURAL SUPERDISINTEGRANTS

Mouth dissolving tablet is the speedly growing and highly accepted drug delivery system. This study was aimed at development of Ketorolac Tromethamine mouth dissolving tablet (MDTs), which can disintegrate or dissolve rapidly once placed in the mouth. Conventional Ketorolac tromethamine tablet require water to swallow it and have limitation like low disintegration rate, low solubility etc. Ketorolac Tromethamine mouth dissolving tablets ( formulation ) consists of super-disintegrate like Heat Modified Karaya Gum, Co-treated Heat Modified Agar & Filler microcrystalline cellulose (MCC). The tablets were evaluated for weight variation, friability, hardness, In vitro disintegration time, wetting time, In vitro drug release profile,content uniformity. The obtained results showed that low weight variation, good hardness, acceptable friability, fast wetting time. Tablets in all batches disintegrated within 15-50 sec. The formulation containing superdisintegrants namely heat modified karaya gum and heat modified agar showed better performance in disintegration and drug release profile.