EVALUATION OF ANTHELMINTIC ACTIVITY OF DI/TRISUBSTIUTED 3-ARYLIDENE-5-(BIPHENYL-4-YL)- 2(3H)-FURANONES

We describe herein the in vitro anthelmintic activity of di/trisubstituted 3-arylidene-5-(biphenyl-4-yl)-2(3H)- furanones against two species of earthworms i.e. Pheretima posthuma and Perionyx excavatus. The anthelmintic activity was determined by noting the mean paralyzing and death times of the worms due to furanone derivatives at a concentration of 2mg/mL. All the tested compounds displayed moderate to good anthelmintic activity but compounds 1 and 5 were found to be the most potent against Perionyx excavatus and Pheretima posthuma, respectively. These exhibited significant anthelmintic activities against both types of worms and the results were comparable to reference drug albendazole. Keywords: Furnaone, Pheretima posthuma, Perionyx excavatus, Anthelmintic