Detection Of Hepatitis B Virus DNA In Moroccan Patients With Epithelial Ovarian Carcinoma EOC By Polymerase Chain Reaction

Abstract Epithelial ovarian cancer EOC is the most common type of ovarian cancer representing 90 of all ovarian cancers. The viruses are known as human malignancies agents. We tried to analyze the presence of Hepatitis B Virus infection in women with epithelial ovarian carcinoma. PCR-based detection of HBV infections was carried out on 50 tissue samples from patients with histologically proven EOC using consensus primers. The samples analyzed showed 8 450 positivity for HBV-DNA in cancerous ovarian tissues. All of the positive patients had serous adenocarcinoma and advanced stage disease. The results of this study suggest that hepatitis B could play a major role in the etiology of ovarian cancer.