Formulation And Evaluation Microcapsules Of Caesalpinia Sappan Linn. Using Emulsion Solvent Evaporation Method

ABSTRACT Caesalpinia extract has widely investigated as a potent source of antioxidants. Its antioxidant activity is majorly due to its high level of phenolic compounds. Microencapsulation is one of the stabilization methods existing to overcome the instability of polyphenol in order to maintain its stability prior to administration. The objective of this research is to encapsulate the caesalpinia extract using emulsion solvent removal method using ethyl cellulose as encapsulating agent and evaluate the physical characteristic and dissolution rate of encapsulated material. The heart wood of caesalpinia plant was extracted using three different solvent 70 ethanol 96 ethanol and destilled water. The three extracts obtained from maceration then measured its antioxidant activity and total phenolic compounds TPC. The 70 ethanol extract shows the greatest TPC 48.36 ww and IC50 in DPPH 3.572 ppm thus this extract was selected to be encapsulated. Microcapsules were prepared with three different drug-polymer ratio used in the formulas 1 3 1 4 and 1 5. These formulas were evaluated for drug encapsulation efficiency microcapsule wall thickness and morphology and also in vitro drug dissolution rate. According to the results obtained in this study the microcapsule with the greatest physical characteristic and dissolution rate that is suitable for sustained release administration is formula III. From this study it is suggested that caesalpinia extract is able to be formulated into microcapsules using emulsion solvent evaporation method and futher developed into sustained release oral preparation as a source of antioxidants.