UV ASSAY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ETODOLAC AND PARACETAMOL IN TABLETS BY SIMULTANEOUS EQUATION METHOD
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.2, No. 11)Publication Date: 2015-11-15
Authors : B. Shailaja; M. Afreen; T. Vinay Kumar; A. Ashok Kumar;
Page : 1468-1473
Keywords : UV; Etodolac; Paracetamol; Assay; validation;
Abstract
Objective: To develop a simple and cheap UV spectrophotometric simultaneous equation method for the simultaneous quantitative estimation of Etodolac (400mg) and Paracetamol (500mg) in tablets and validate as per ICH guidelines. Method: The optimized method uses 100% Triethylammonium phosphate buffer (pH 10) as a diluent for the simultaneous quantitative estimation of Etodolac and Paracetamol in tablets by UV spectroscopy by simultaneous equation method. Results: The developed method exhibited linearity in the range of 5-15μg/ml for Etodolac and 6.25-18.75μg/ml for Paracetamol. The precision for Etodolac and Paracetamol is exemplified by relative standard deviation of 0.176% and 0.246 respectively. Percentage Mean recovery for Etodolac and Paracetamol were found to be in the range of 90‐110, during accuracy studies. Conclusion: A simple and a cheap UV spectrophotometric method was developed and validated for the simultaneous quantitative estimation of Etodolac and Paracetamol in tablets as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries. Keywords: UV, Etodolac, Paracetamol, Assay, validation
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Last modified: 2015-11-15 02:29:51