Comparative efficacy of antiepileptic drugs and lacosamide in patients with epilepsy due to an underlying brain lesion

Aim: We aimed to compare the efficacy of other antiepileptic drugs (AEDs) to lacosamide (LCM) in patients with epilepsy due to an underlying brain lesion. Methods: Total fifty patients were screened for the study. The sociodemographic data, side effects, frequency of seizures recorded and neurocognitive rating scales were applied in all patients fulfilling the inclusion criteria. Patients were given LCM in doses range of 6-8 mg/kg body weight. Follow up were done at monthly interval for three months. Results: We found prevalence of seizures and encephalitis of brain was more common in rural and low socioeconomic status patients in all age groups. Maximum patients were receiving add-on AEDs therapy of two or more drugs. The patients with seizures in post encephalitis of brain and sequelae were less tolerated to higher doses AEDs and its combinations. 86.25% patients had severe neurological/systemic side effects and the mean seizures control were