Formulation and evaluation of fluvoxamine maleate matrix tablets using gum kondagogu

Gum Kondagogu is a naturally obtaining gum from the Cochlospermum species which is abundantly available in the forest regions of Andhra Pradesh. It has many pharmaceutical applications like matrix forming, film forming substance among them the controlled release nature had been explored. Fluvoxamine Maleate is a selective serotonin reuptake inhibitor and it has shown very good results when administered in controlled release dosage forms. The various matrix formulations have been prepared and evaluated for pre and post compression parameters which showed the results in acceptable limits. Among them the formulation containing 50% of Gum Kondagogu and 10% of HPMC K100M had shown a very similar release profile with that of commercial. The FTIR, DSC studies showed that there are no interactions between the excipients and the drug. The better formulation had shown a stable release profile after being kept for accelerated stability conditions for a period of three months. Kondagogu gum is a suitable rate controlling polymer for the preparation of once daily Fluvoxamine Maleate extended release tablets.