Mechanisms of Development of Hypothalamic Pubertal Syndrome in Children

The analysis of Ukrainian and foreign literature with the aim to study the causes, mechanisms of development, the main approaches to classification, and clinical manifestations of hypothalamic pubertal syndrome in children and adolescents was made. An overview of the literature showed the importance of in-depth analysis of hypothalamic pubertal syndrome in children and adolescents and a number of options to solve the problem was identified. Medical and social importance of hypothalamic syndrome is determined by young age of patients, rapidly progressive disease course, severe neuroendocrine disorders which are often accompanied by reduced or total disability. The objective of the research was to consider hypothalamic pubertal syndrome in children and adolescents as neuroendocrine syndrome occurring during puberty and post puberty as a result of functional disorders of the endocrine system. In most cases it was difficult to find out its main cause as manifestations often occurred some years after the action of the causal factor leading to serious reproductive-health consequences among girls (infertility, polycystic ovary syndrome, subsequent obstetric and perinatal complications). Set of symptoms associated with pathological changes in the hypothalamic region characterized by autonomic, endocrine, metabolic and trophic disorders and dependent to some extent on the localization of lesions in the hypothalamus and features of violation of neurohormonal regulation of hypothalamic-pituitary relationships was studied. It could also be argued that the main pathogenetic and clinical aspect of hypothalamic pubertal syndrome is hypertension. The mechanisms contributing to the relationship between hypertension and obesity are complex and multifactorial.