Dual Choice For Dual Target Anti-HIV Therapy

The approval of raltegravir (Isentress®, Merck & Co.) in 2007 by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS provided novel therapeutic options for patients failing existing therapies. The use of this first HIV integrase inhibitor (INI) in the clinic had a major impact on the outcome of the disease. The antiretroviral therapeutic arsenal is now complete to target the three retroviral enzymes, reverse transcriptase (RT), protease and integrase (IN).