Gastroesophageal Reflux Disease and Metabolic Syndrome

Purpose of the research is to study the features of gastroesophageal reflux disease, combined with the metabolic syndrome. Materials and methods. The study involved 490 patients (250 have got gastroesophageal reflux disease, combined with the metabolic syndrome and 240 have got gastroesophageal reflux disease without the metabolic syndrome). The patients besides general clinical examination were carried out video-fibro-gastro-duodeno-skopy, pH-monitoring in the esophagus, anthropometry, determination of body mass index, proportion of fat and muscle tissue in the body and basal metabolic rate. Results. It was found that symptoms of heartburn and bloating can serve as reliable diagnostic criteria gastroesophageal reflux disease, combined with the metabolic syndrome. For the diagnosis of metabolic syndrome, these anthropometric indicators are the most valuable: body mass index (>27.0 kg/m2) abdominal obesity (abdominal perimeter in men > 94 cm, in women - > 80 cm), increasing the intensity of the basal metabolic rate (>1500 kcal/day). Risk factors for gastroesophageal reflux disease, combined with the metabolic syndrome are dangerous for male gender, age over 40 years. There is a significant difference between body mass index values calculated from height and weight and body mass index defined by bioelectric impedance. This difference in patients with gastroesophageal reflux disease increases over the deeper changes of endoscopic esophageal mucosa. Conclusions. Epigastric pain is a sign of reflux-oesophagitis. Presence and severity of reflux-esophagitis can be set only during endoscopic examination of patients. More pronounced intensity of pain in comorbidity can be explained by the presence of common pathogenetic links gastroesophageal reflux disease and metabolic syndrome leading to greater frequency of erosive lesions of the esophagus, stomach and dudenal indigestion.