Advantages of modified drug delivery system in psychiatry

Non-compliance is a common problem in chronic diseases including psychiatric disorders. Various attempts have been made for improving adherence in psychiatry; one of them being simplifying dosage regimen by designing modified dosage formulation. For example, depot formulation, oral disintegrating tablets or extended release formulations are some of the strategies for improving compliance in psychiatry patients. Modified dosage formulations also have some other advantages too. For example, oral disintegrating tablet of olanzapine cause lesser weight gain compared to standard olanzapine tablet while Zolpidem extended release tablet provides better sleep maintenance in middle of night. This article reviews some of the modified dosage formulations in psychiatric diseases with their advantages. [Int J Basic Clin Pharmacol 2013; 2(4.000): 368-370]