IMMUNOLOGICAL TESTS COMPARISON FOR THE DETECTION OF HELICOBACTER PYLORI INFECTION IN EGYPTIAN ADULT PATIENTS

Helicobacter pylorus (H. Pylori) is one of the most important human pathogens, infecting more than 50% of the human population. Commonly the first noninvasively testes used for H. pylori infection's detection were immunological tests like blood antibody test and stool antigen test. We investigated the more efficient susceptibility immunological test for detection of H.pylori infection in adult Egypti an patients by comparing the results of H. Pylori IgA (HpIgA), IgG in serum blood (HpIgG) and H.pylori Ag in stool(HpSAg) for 30 adult patient (males and females) against control group using ELISA technique. The results showed that each test could be used successfully for diagnosis of H. pylori with 100% specifity and PPV% with no gender relation. Finally HpSAg showed reliable results with high sensitivity (> 95%) followed by HpIgG (87.5%), while HpIgA showed the lowest sensitivity (37.5%). Our findings con firms the use of the mentioned immunological tests for detecting the H. Pylori infection and suggest the use H. Pylori Ag in stool as the most economic, sensitive and reliable method alone or followed by IgG antibody test as confirmatory test to be the f irst choices for early diagnosis of H. Pylori espe cially in developing countries