Development and evaluation of fast mouth dissolving tablets of Terbutaline sulphate using two different techniques
Journal: MIT International Journal of Pharmaceutical Sciences (MITIJPS) (Vol.1, No. 1)Publication Date: 2015-01-26
Authors : Vikas Saxena; M. Hoque;
Page : 45-47
Keywords : ? Terbutaline Sulphate ? Direct compression ? Sublimation ? Mouth dissolving;
Abstract
Fast mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study two different methods direct compression and sublimation in formulation of mouth dissolving tablets of Terbutaline Sulphate. Total four formulations using various superdisintegrants and subliming agents were prepared. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 25 to 35 s. Comparative evaluation of two methods showed direct compression method is a better alternative to sublimation method as its formulations rapidly disintegrate in oral cavity. In vitro cumulative percentage drug release for formulations prepared by direct compression with explotab superdisintegrants shows 99.79 while sublimation method using camphor 93.58 release in 12 min. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism.
Other Latest Articles
- Design and characterization of solid dispersion based fast dissolving tablet of Cetirizine hydrochloride
- Novel interpenetrating polymer network mucoadhesive microspheres of locust bean gum and poly(vinyl alcohol) for the delivery of Famotidine
- Synthesis and antimicrobial activity of some novel derivatives of 7-hydroxy-4- methyl coumarin
- Nitazoxanide stabilizing hypsochromic shift based method for its determination in bulk and in pharmaceutical formulation
- A seizure with a spot: a study of patients with mesial temporal lobe epilepsy
Last modified: 2015-12-10 15:28:46