Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity

Dithiocarbamates (DTC) are well known compounds to bind strongly and selectively to many metal ions, so in the past few years self-assembly directed by metal?dithiocarbamate coordination has emerged as a useful supramolecular methodology for the preparation of macrocycles, cages, catenanes, and nanoparticles. Most of the applications are based on complexation properties of DTC ligands with metal ions, especially with transition metal ions. DTC ligands readily form chelates with all transition metal ions through its two donor sulfur atoms. In the present investigation carried out a synthesis of as such new dithiocarbamates derived from unique series of heterocyclic amines, 4 ?amino 1,2,4-triazole ,2-amino-3-hydroxy pyridine, 3-amino-9-ethyl carbazole, furfryl amine and 2-amino-4-hydroxy-6-methyl pyrimidine with Carbon disulphide, and characterized using elemental analyses, FT-IR, NMR. The antibacterial activities of synthesized compounds were studied against two Gram-negative species, Escherichia coli, Klebsiella pneumoniae and one Gram-positive species, Bacillus subtilis.