Formulation and evaluation of ranitidine loaded eudragit rs100 microspheres

BACKGROUND: Microencapsulation is an innovative process by which small particles like solids and liquids are entrapped in a uniform shell. Microencapsulation technique employs coating of very small particle with protecting coating by various polymers with high potential that retards the drug release. Ranitidine is a histamine H2 receptor antagonist that restrain acid secretion in the stomach. More widely it is used in the treatment of peptic ulcer and gastroesophageal disease. AIM: The rationale that lies behind this technique is to achieve a controlled and delayed release with enhancement of stability and good shelf life. In the present study ranitidine loaded Eudragit RS100 microspheres were prepared by three different methods, characterized and evaluated to get more prolonged and effective delivery of ranitidine. MATERIALS AND METHODS: Three batches of Ranitidine loaded Eudragit RS 100 were prepared by solvent evaporation technique using the drug to polymer ratio (1:4), organic phase to aqueous phase ratio (1:5) and stabilizer concentration (1% w/v). Three batches of RES3 showed reproducibility of the products. The , particle size, yield and entrapment efficiency of RES3 which show there is prominent sustained drug release attributed on the nature of polymer. RESULTS AND DISCUSSION: The particle size measured by SEM was relatively smaller than the particle size measured by Malvern particle size analyzer. The drug release from the formulation RES3 was slow and extended beyond 12 h up to 24 h . After 4 h the rapid drug release occurred due to of polymer erosion in the surface of microspheres and consequent release of drug which has been loaded near the surface of the microspheres. It obeys Higuchi and Peppas equation suggesting mechanism for drug release from the microspheres follows diffusion an dissolution. CONCLUSION: RES3 batch showed good stability makes it a promising tool for sustained drug delivery and will enhance patient compliance. Hence it is concluded that is concluded that the method of preparation of microspheres was found to be simple, reproducible, and provides good yield.