EFFECT OF DISINTEGRANTS ON IN VITRO RELEASE OF FENOFIBRATE ORO-DISSOLVING TABLETS
Journal: Bulletin of Pharmaceutical Research (Vol.2, No. 1)Publication Date: 2012-04-30
Authors : Ramadevi Bhimavarapu Karuna Priya Chitra Dhavani Kanikanti Manasa Anne Haritha Meda N. Gowthami;
Page : 10-14
Keywords : Fenofibrate; Oro-dissolving tablet; Direct compression; Superdisintegrants;
Abstract
Fenofibrate is a widely used hypolipidemic drug of the fibrate class. The poor aqueous solubility of the drug leads to variable dissolution rates. The present investigation reports development and characterization of fenofibrate oro-dispersible tablets using direct compression technique. Oro-dispersible tablets of fenofibrate were prepared using different concentrations of super disintegrating agents like crospovidone and sodium starch glycolate by direct compression method. The formulation blends were examined for angle of repose, bulk density and tapped density. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, wetting time, in vitro disintegration time, and in vitro dissolution studies. The formulation CP-3 was found to be the best as it exhibited least wetting time (43 sec) and disintegration time (26.40 sec) and best in vitro drug release (96.402%) as compared to other tablet formulations.
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