MAJOR TRENDS IN THERAPEUTIC NEOANGIOGENESIS IN TREATMENT OF CHRONIC LOWER LIMB ISCHEMIA (LITERATURE REVIEW)

Artificial induction of novel formation of vessels is referred to as therapeutic neoangiogenesis, i.e. a strategy of improvement of perfusion of ischemic tissues due to enhanced natural angiogenesis which is upregulated by a number of angiogenic factors. There are certain technologies used for therapeutic neoangiogenesis, such as gene therapy, cell therapy, genetically modified cell therapy and post-genomic technologies (recombinant growth factors). Genetic constructions are widely researched and are registered in several countries for treatment of chronic lower limb ischemia while cell therapy and post-genomic technologies are currently researches in experiment or phase 1-2a clinical trials. Hereby is a literature review of current trends in therapeutic neoangiogenesis.