SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME INNOVATIVE SILICON SCHIFF BASE COMPOUNDS

A new series of bio effective organosilicon, (IV) complexes were isolated as coloured solids soluble in most of the organic solvents. These compounds were prepared by the reaction of trimethylsilicon chloride and triphenylsilicon chloride with the hydrazin ecarboxamide and hydrazinecarbothioamide ligands of Schiff bases in 1:1 stoichiometry give complexes having general formula [R3Si(LlH)], [R3Si(L2H)], [R3Si(L3H)], [R3Si(L4H)], where R= triphenyl and trimethyl. Their molecular weight determinations show tha t the complexes are monomeric in nature. Conductivity measurement values in DMF lie in the range of 10 - 12 ohm - 1 cm2 mol - 1 indicate them to be non - electrolyte. The coordination behaviour and bonding pattern of these compounds are discussed by the support of electronic, infrared and multinuclear magnetic resonance (1H, 13C and 29Si NMR) spectral studies. These analyses suggest that the ligands act in a bidentate manner, coordinating metal through the oxygen/sulphur and nitrogen atoms. Trigonal bipyramidal geo metry is assigned for 1:1 metal complexes. All the schiff base ligands and their corresponding organosilicon complexes have also been screened for their antifungal and antibacterial activities against Gram - positive bacterial strain (Staphylococcus aureus) and Gram - negative bacterial strains (Escherichia c oli and Pseudomomas cepacicala)