Analgesic and anti-inflammatory effect of an aqueous extract of Dendrocnide sinuate (Blume) Chew

The study was aimed to evaluate the analgesic and anti-inflammatory effect of aqueous root extracts of Dendrocnide sinuata (Blume) Chew (AEDS) in Swiss albino mice and wistar rats. The animals were orally administered AEDS at doses 30 and 100 mgkg-1 (p.o). For analgesic study, acetic acid-induced Writhing test, Eddy’s hot plate and Tail Flick model was performed in mice. For antiinflammatory study, carrageen-induced paw edema study was performed in rats. In acetic acid induced model, effect of AEDS was comparable with the standard meloxicam 10 mgkg-1 (i.p). In the hot plate model, the maximum effect was observed at 30 min at a dose of 100 mgkg-1 (p.o) which was comparable with the standard Pentazocine 10 mgkg-1 (p.o), whereas in the tail flick model no significant changes were observed. In the carrageenan-induced paw edema model, administration of AEDS showed significant (P < 0.05) dose dependent inhibition of edema formation. AEDS was effective in both narcotic and non-narcotic models of analgesia. It also showed a significant dose-dependent increase in antiedematogenic activity which revealed good peripheral anti-inflammatory properties of the extract.