FORMULATION AND EVALUATION OF LABETALOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET BY USING HIBISCUS ROSA-SINENSIS LEAVES MUCILAGE AND POVIDONE

The purpose of the present work was to develop matrix tablets of Labetalol HCl with Hibiscus rosa-sinensis leaves mucilage and povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from the Hibiscus rosa-sinensis leaves was extracted, isolated, and characterized. Physicochemical properties of dried mucilage powder of Hibiscus rosa-sinensis leaves were studied. Sustained release formulations of Labetalol HCl were prepared by using mucilage and povidone. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in-vitro drug release pattern and the dissolution data (subjected to mathematical modeling). The formulated tablets were found to have good mechanical properties and good swelling properties. The in-vitro dissolution data was fitting to zero order kinetics and the release of drug from the formulation was found to follow Korsemeyer Peppas release. From this study it was concluded that the dried mucilage of Hibiscus rosa-sinensis leaves and povidone combination can be used as an effective matrix forming material for making sustain release matrix tablets of Labetalol HCl. Key Words: - Sustain release, Matrix tablets, Labetalol HCl, Hibiscus rosa-sinensis, Povidone.