FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF TELMISARTAN IN PHARMACEUTICAL FORMULATION

In present investigation, UV first derivative spectrophotometric methods has been developed for the determination of telmisartan in pharmaceutical formulation. The solutions of standard and sample were prepared in 0.1 M sodium hydroxide. In the UV spectrophotometric method, the quantitative determination of the drug was carried at 295 nm and the linearity range was found to be 4-20 μg/ml. For the first order derivative spectrophotometric method, the drug was determined at 311 nm with the linearity ranges 4-20 μg/ml. The calibration graphs constructed at their wavelength of determination were found to be linear for UV and derivative spectrophotometric methods. The proposed methods have been extensively validated. There was no significant difference between the performance of the proposed method regarding the mean values and standard deviations. The described method can be readily utilized for analysis of pharmaceutical formulation.