The Use of Hyaluronidase in Cosmetic Dermatology: A Review of the Literature

Background: Hyaluronidase can be employed to manage a variety of complications associated with cosmetic hyaluronic acid (HA) filler injection. However, the indications and treatment protocol for hyaluronidase use have not been well established. Objective: Review of the available literature to describe the use of hyaluronidase in the reversal of HA filler injection. Methods: PubMed/MEDLINE databases were utilized to identify case reports and studies pertaining to the use of hyaluronidase after HA filler injection. Results: Hyaluronidase can be successfully employed in the management of uncomplicated nodules and overcorrection, inflamed nodules, or tissue ischemia associated with HA filler injection. Hyaluronidase use is dependent on the clinical indication, anatomical location, and original injected HA quantity. Conclusion: Hyaluronidase is an important tool for clinicians utilizing cosmetic HA filler injection. Further reports and studies are warranted to firmly establish the ideal treatment protocol.