USE OF SOME INFUSION SOLUTIONS IN ORDER TO IMPROVE PERFUSION IN CEREBRAL ISCHEMIA IN EXPERIMENT

The therapeutic effect of colloid-hyperosmolar solution under laboratory code HAES-LX-5%, colloid-isoosmolar solution voluven and isoosmolar 0.9% NaCl solution in different dose regimes ? 2.5, 5 and 10 ml/kg 30 minutes after ischemia ? was investigated in rats with the model of acute ischemic disorder of cerebral circulation (bilateral carotid occlusion). It was found that none of the studied regimens of administration of 0.9% NaCl solution did not provide significant reduction of mortality in the critical period of the experiment relative to the control group pathology (p<0.05) except 10 ml/kg q.d. Voluven showed the optimal therapeutic effect at a dose of 5 ml/kg q.d. (p<0.05). Maximally powerful therapeutic effect of all the tested solutions was demonstrated by HAES-LX-5% at a dose of 2.5 ml/kg b.i.d.