Pleomorphic Adenoma and Histologically Analogous Tumors of Usual and Unusual Sites: An Eight Year Experience in Muzaffarnagar Region

Introduction: Case reports of pleomorphic adenomas of usual and unusual sites form a wonderful data in clinical and pathological literature. Pleomorphic adenoma is a biphasic tumor & characterized by admixture of polygonal epithelial & spindle shaped myoepithelial cells in a variable stromal background. Term “Mixed” benign tumor begets from such architecture. Aims and Objectives: The aim of the present study was to highlight the various clinicopathological aspects of pleomorphic adenoma and anatomically analogous tumors of various sites in our archives. Materials and methods: We performed an analysis of clinicopathological features of all “mixed tumors” from our archives. Observation and Results: In our study we studied 39 cases of pleomorphic adenomas from various sites. A few cases were unusual in terms of locations, size and presentation. Most common site is parotid salivary gland. Extra-parotid sites are submandibular glands, minor salivary glands, skin, external auditory canal and vagina etc. Wide surgical excision is treatment of choice. Histopathological diagnosis is rarely difficult. Immunohistochemistry (IHC) is mandatory, in case of suspicion. Conclusion: The results from the present study displayed the various presentations, locations and variability on histopathological architecture, thus highlighting the various clinicopathological aspects of pleomorphic adenoma and anatomically analogous tumors. IHC is required in difficult cases.